Peter O. Behan, a professor of neurology at the University of Glasgow, wrote a review regarding multiple sclerosis (MS) and it’s being a true autoimmune complication at Expert Review.
He showed due diligence with a serious amount of references that will make a person sit up and pay attention.
Prof. Behan brings up, first and foremost, the mouse model for MS and its steady use for almost all clinical trials done here in the US, there in the U.K. and other countries.
He talks of how MS resembles acute disseminated encephalomyelitis (ADEM), a disease that occurs following a viral infection but may appear following vaccination, bacterial or parasitic infection, or even appearing spontaneously and discusses how, because of this, the EAE also became a mouse model for MS despite it not yet being proven conclusively for MS as it was for ADEM.
ADEM and EAE are shown to be comparable, but MS is largely a different disease since the last two decades of clinical trials have not been able to prove MS as being like other autoimmune disorders. Prof. Behan’s disturbing look over researchers ignoring this is shown in how of “the 487 clinical trials for MS currently being published on the NIH website alone, 94 are open studies testing various drug interventions, how of the 94, 30 are for testing drugs for pain relief, spasticity, memory retrieval, depression and fatigue and the remainder is testing immunmodulatory drugs founded on the EAE model for MS with MS being the disorder.”
An audit of these trials show some researchers disagreeing about methodology (means, techniques, or procedures) of the trials and in others the placebo group did better, much better, than those taking the active drug. Also distressing is the Cochrane Review discussing the benefits of interferon in relapsing-remitting MS where only seven in the 208 articles showed all selection criteria being met.
“This so upsets me,” says Linda Haven, an MS sufferer from Lima, OH. “I’ve been going downhill steadily for years and I get so focused on just treating the symptoms, have always just excepted what they tell me, and apparently I shouldn’t have? I mean, I understand the difference between the NIH and other studies stateside that are published, but, they would be awful close to being the same wouldn’t they?”
Prof. Behan also brought up the side effects of immunosuppressive drugs to show how using EAE as a model for MS muddies the water on finding a cure. The usage can cause an array of strange and rare and extra complications, along with having MS, such as leukoencephalopathy, a progressive degenerative condition of the brain and malignant melanoma and other tumors; making the MS worse as it were.
Patrick Lutrell, also an MS sufferer from Lima, has this to say about his chemotherapy treatments, “I’ve done so many chemo treatments for this disease that my neurologist has informed me that I need a break. I’ve not been a statistic where I’ve gotten luekemia, thankfully, but my white blood cells are shot all the time, and I pick up every cold germ out there which could land me at Lima Memorial for an extened stay if I’m not careful.”
The disclosure shows Prof. Behan as not having any affiliations or financial involvements with organizations that would either benefit or lose out on his thoughts and, as stated above, there are many references and websites he is using to back up it up. It is a well detailed paper with a great deal more information than supplied here.
If interested in reading on it, please click HERE.
For More Reading by Peter O. Behan:
- Annals of Internal Medicine: Chronic Fatigue
- BMJ: Shared Scheme for assessing drugs for Multiple Sclerosis
For more info: for those who live in Lima, Ohio, the Northwestern Ohio MS Chapter can be reached at: 401 Tomahawk Drive , Maumee, OH at (419) 897-7263. They are located approximately an hour and a half from Lima, Ohio and 45 minutes from Findlay, Ohio. For directions please click here at Google Maps.
sources: MSRC www.msrc.co.uk/index.cfm/fuseaction/show/pageid/7; Expert Review
For any corrections of factual information or to contact the writer please use – LWF.Examiner@Gmail.Com
Make your voice heard. “Subscribe” above and post your comments, questions and opinions.
Follow Lori Friend on twitter @: twitter.com/lwilsonfriend